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KMID : 0043319880110010007
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Archives of Pharmacal Research
1988 Volume.11 No. 1 p.7 ~ p.13
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Cytochrome C methylation: Current Knowledge of its Biological Significance
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Park KS
Frost BF/Lee HW/Kim SD/Paik WK
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Abstract
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The yeast cytochrome c gene has been recloned, and the resulting cytochrome c mRNA has been translated in rabbit reticulocyte lysate translation system. The newly synthesized apocytochrome c could be methylated by exogenously added cytochrome c-lysine N-methyltransferase. Enzymatic methylation of in vitro synthesized apocytochrome c was found to facilitate specifically its import into mitochondria of yeast, but not of rat liver.
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